LSD1 & CNS

LSD1 is expressed in many tissues of the human body, from the embryonic process to adult life. One of the tissues where LSD1 plays a more important role is the brain. It intervenes in the first stages of life helping the neuronal division in order to ensure that all neurons that will be needed later in adult life are produced. After birth, multiplication stops and neurons differentiate, travel to their target sites and establish the myriad of connections that will ensure the correct functionality of the various brain areas. LSD1 also plays a very important role in this process. In several neurological and psychiatric diseases, deregulation of the activity of LSD1 can occur.

In animal models of Alzheimer, Huntington, schizophrenia and psychosis, LSD1 inhibition results in an improvement of short and/or long term memory. LSD1 inhibition also improves aggressive behavior and increases sociability in animal models. In certain models it has been shown that LSD1 inhibition produces axonal and synaptic branching of neurons, that is, an improvement in their ability to connect with neighboring neurons. Finally, LSD1 is also involved in inflammatory processes, and LSD1 inhibitors have been shown to reduce inflammation and clinical signs in different preclinical models of multiple sclerosis. Inflammation is a pathophysiological process that has been shown to play a role in neurodegenerative diseases such as multiple sclerosis or Alzheimer's disease as well as in psychiatric diseases.